I've been using Cryptainer LE for encrypting data on my HD for over a year. Very happy with it.
Cryptainer LE - Software Downloads and Reviews
Roboform is super convenient the way it integrates with FireFox. Only downside is you have to pay for it if you need more than 10 passwords (which I do). I've used KeePass for several months and I like it a lot. It's completely free because it's open source. One feature I especially like is the option for creating a CD key. The CD must then be inserted before entering your password to unlock KeePass. It creates a physical security layer.
KeePass Password Safe - Software Downloads and Reviews